Translational Cancer Research

Cancer is a topic which touches many. In this fight, the researchers of the Virginia Tech - Wake Forest University School of Biomedical Engineering and Sciences employ many tools. Treatments using electroporation and microfluidics battle cancers such as glioblastoma. Diagnosis and treatment planning are being developed using existing and emerging technologies.

Bahareh Behkam

Bahareh BehkamThe Micro/NanoScale Biotic/Abiotic Systems Engineering Laboratory research interest is in experimental and theoretical investigation of phenomena at the interface of biological and synthetic systems (or bio-hybrid engineering) at the micro and nanoscale. Current research activities can be divided into two broad categories: (1) Developing bio-hybrid engineered systems in which biological components are utilized for actuation, sensing, communication, and control (e.g. bacteria-enabled autonomous drug delivery systems for cancer therapy) (2) Studying mechanism of adhesion, motility and sensing in mammalian cells and unicellular microorganisms (e.g. effect of surface nanotopography on fungal biofilm formation).

Location: Virginia Tech campus

Rafael Davalos

Rafael DavalosDavalos’ research interests are in developing minimally invasive techniques to treat cancer, engineering approaches to create tissue scaffolds for regenerative medicine, and microfluidic-based approaches for detecting cancer and precision medicine.

Location: Virginia Tech campus

Metin Gurcan

Metin GurcanThe qualitative analysis of histopathological and radiological images is time-consuming and subject to inter- and intra-reader variations. This affects the prediction of the clinical outcome in an undesirable way. As a result, we are developing image analysis systems for computer-assisted interpretations of these images to help pathologists and radiologists in their analysis of images. Our goal is to provide computational tools with which they can extract quantitative features useful for more objective and accurate detection, diagnosis, and prognosis. In addition, we are investigating high performance computational infrastructures to efficiently process these large images. The current systems developed in our Clinical Image Analysis (CIALAB) have provided promising results - both in terms of accuracy and also computational efficiency.

Location: Wake Forest campus

Adam Hall

Adam HallOur lab’s focus is on advancing micro- and nanotechnologies towards translational applications. This is pursued in two central directions. First, we develop novel measurement strategies using the solid-state nanopore platform: a fabricated nanodevice capable of probing individual biomolecules electrically. With this, we are able to detect a range of biomarkers of disease, including target nucleic acid sequences, epigenetic modifications, and agents of autoimmune disorders like Celiac’s disease. Second, we combine 3D cell culture techniques with microfluidic delivery systems. Here, we are uncovering the biology of cancer progression and metastasis, and building towards patient-specific drug screening.

Location: Wake Forest campus

Bethany Kerr

Bethany KerrThe Kerr lab is focused on uncovering the mechanisms driving cancer metastasis with an emphasis on prostate cancer bone metastasis. Our goal is to discover new biomarkers capable of differentiating patients likely to progress to metastasis from those with indolent disease. Within the primary tumor, we study angiogenesis, extracellular matrix proteins, and cancer stem cells. In the circulation, we focus on platelets and disseminated tumor cells. We use live cell imaging, 3D cell culture systems, and in vivo fluorescent imaging among other methodologies to examine metastatic initiation and spread.

Location: Wake Forest campus

John Rossmeisl

John RossmeislI develop and test novel treatments for brain cancers using dogs with naturally occurring brain tumors as a translational model.

Location: Virginia Tech campus

Scott Verbridge

Scott VerbridgeIn the Verbridge Laboratory for Integrative Tumor Ecology (LITE), we take a highly interdisciplinary approach to both understanding cancer progression, and developing novel targeted therapies. Our current NIH-supported research is focused on two key topics: 1) leveraging the altered physical properties of tumor tissues, particularly the altered electrical capacitance of malignant cells, to enable their preferential destruction, and 2) analyzing the role of tissue-resident bacteria in regulating tumor cell stress response during tumor development and therapy. The overarching theme running through this work is the development of cutting edge tissue engineered models of the tumor microenvironment to analyze key processes and interactions which would be intractable in vivo.

Location: Virginia Tech campus

Jared Weis

Jared WeisThe overall theme of my research is concentrated in applying computational modeling and non-invasive imaging methodologies to explore the nature of soft-tissue mechanics in cancer and development, with an emphasis on driving clinical therapeutic interventions. Research focuses on the multi-disciplinary study of the multi-scale influences of mechanics in cancer progression and response to therapy, involving the development and validation of imaging-based mathematical modeling approaches to evaluate and parameterize biophysical properties of cancer and predict responsiveness to therapy.

Location: Wake Forest campus

Dawen Zhao

Dawen ZhaoDevelopment of theranostic agents for brain tumor diagnosis and treatment. Development of image-guided drug delivery system to cross the BBB to treat brain tumors.

Location: Wake Forest campus

Faculty with Related Interests

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