Mark Van Dyke, Ph.D.
School of Biomedical Engineering and Sciences
226 ICTAS II, Washington 0917
Blacksburg, VA 24061
- B.S., Central Michigan University, Mt. Pleasant, MI, 1988
- Ph.D., University of Cincinnati, Cincinnati, OH, 1998
Nanostructured Biopolymer Engineering Lab - Mark E. Van Dyke, Ph.D.
Biomaterials are an essential tool that provide the basis for bioengineered devices, growing and delivering cells, developing functional tissues, and engineering whole organs. Natural biopolymers that self-assemble on the nano scale have the potential to provide native cellular environments that facilitate the directed behavior of cells. Research conducted by the Nanostructured Biopolymer Engineering Lab makes use of naturally derived structural proteins for biomaterials development. Using primarily keratin proteins, Dr. Van Dyke’s research group creates matrices and scaffolds used for tissue engineering and trauma applications, and studies their fundamental characteristics such as molecular self-assembly and structure-function relationships. Keratins can be purified from end-cut human hair fibers and when properly isolated, demonstrate several remarkable characteristics. First, keratins are highly biocompatible because they come from human tissue. Purified materials contain no cellular elements so they do not elicit an immune response between individual donors. Second, certain keratins have an incredible ability for molecular self-assembly that results in the spontaneous formation of network structures. Self-assembly occurs on the nanometer scale and builds to the micron scale, resulting in homogenous, porous architectures that are conducive to cell attachment and growth. Third, keratin proteins contain cellular binding motifs that mimic the sites of cell attachment found in the native extracellular matrix. By leveraging these unique characteristics, we are creating inexpensive biomaterials for a host of biomedical applications. Commercializing the results of our research is also a focus of the lab. Our current research programs are directed toward developing greater understanding of the molecular self-assembly process and keratin’s ligand-like function. Moreover, we have projects that are aimed toward clinical applications such as bone tissue engineering, spinal cord injury, peripheral nerve regeneration, and osteoporosis. Dr. Van Dyke is also appointed to the Department of Orthopaedic Surgery at Wake Forest University School of Medicine and maintains a lab at the Musculoskeletal Center of Research Excellence (MSCoRE) at Wake Forest, giving colleagues and trainees access to unique and productive clinical collaborations.
- Burnett L, Rahmany MB , Richter J, Aboushwareb T, Eberli D, Ward C, Orlando G, Hantgan R, Van Dyke M. Hemostatic properties and the role of cell receptor recognition in human hair keratin protein hydrogels. Biomaterials 2013;34(11):2632-40
- Rahmany MB, Hantgan RR, Van Dyke M. A mechanistic investigation of the effect of keratin-based hemostatic agents on coagulation. Biomaterials. 2013;34(10):2492-500
- de Guzman RC, Saul JM, Ellenburg MD, Merrill MR, Coan HB, Smith TL, Van Dyke ME. Bone regeneration with BMP-2 delivered from keratose scaffolds. Biomaterials 2013;34(6):1644-56
- Rahmany MB, Van Dyke M. Biomimetic approaches to modulate cellular adhesion in biomaterials: A review. Acta Biomater 2013;9(3):5431-7
- Gaines C, Poranki D, Du W, Clark RAF, Van Dyke M. Development of a porcine deep partial thickness burn model. Burns 2013;39(2):311-9
- Whitlock PW, Seyler TM, Parks GD, Smith TL, Van Dyke ME, Poehling GG. A novel process for optimizing musculoskeletal allograft tissue: Improving safety, ultra-structural properties and cell infiltration. J Bone Joint Surg Am 2012;94(16):1458-67
- Bertram TA, Tentoff E, Johnson PC, Tawil B, Van Dyke M, Hellman KB. Hurdles in tissue engineering/regenerative medicine product commercialization: a pilot survey of governmental funding agencies and the financial industry. Tissue Eng Part A 2012;18(21-22):2187-94
- Van Dyke M. How much risk are you prepared to take? Nat Biotechnol 2012;30(9):821-4
- Coan HB, Teli T, Booth C, Lively MO, Van Dyke M. Cell-secreted matrices enhance osteogenesis in adipose-derived stem cells undergoing lineage specification. J Biomim Biomater Tissue Eng 2012;14:1-30
- Stern AR, Stern MM, Van Dyke ME, Jähn K, Prideaux M, Bonewald LF. Isolation and culture of primary osteocytes from the long bones of skeletally mature and aged mice. Biotechniques 2012;52(6):361-73
- Orlando G, Wood KJ, De Coppi P, Baptista PM, Binder KW, Bitar KN, Breuer C, Burnett L, Christ G, Farney A, Figliuzzi M, Holmes JH 4th, Koch K, Macchiarini P, Mirmalek Sani SH, Opara E, Remuzzi A, Rogers J, Saul JM, Seliktar D, Shapira-Schweitzer K, Smith T, Solomon D, Van Dyke M, Yoo JJ, Zhang Y, Atala A, Stratta RJ, Soker S. Regenerative Medicine as Applied to General Surgery. Ann Surg 2012;255(5):867-80
- Stern AR, Stern MM, Van Dyke ME. Transduction of strain to cells seeded onto scaffolds exposed to uni-axial stretching: A three-dimensional finite element study. J Mech Med Bio 2012;12(1):1250022-1-16
- Lin YC, Ramadan M, Van Dyke, M, Kokai LE, Philips BJ, Rubin JP, Marra KG. Keratin gel filler for peripheral nerve repair in a rodent sciatic nerve injury model. Plast Reconstr Surg 2012;129(1):67-78
- Richter JR, de Guzman RC, Greengauz-Roberts, Van Dyke ME. Structure-property relationships of meta-kerateine biomaterials derived from human hair. Acta Biomater 2012;8(1):274-81