SBES Neuroengineering interfaces with vibrant neurosciences to find solutions to issues such as abnormal brain function, neurological and psychological diseases. New techniques are explored for therapy and rehabilitation. Research is highly collaborative, using the rich resources of the Virginia Tech - Carilion Research Institute and the Wake Forest School of Medicine. Cutting-edge technology such as the 3D Tesla MRI provide highly effective tools for study and analysis.
The Chappell Lab studies how blood vessel formation occurs and in particular how cells known as pericytes migrate along developing vessels and ultimately wrap around and stabilize new vasculature. We develop computational models alongside experimental approaches to understand these processes, as well as engineer new therapeutic approaches to treat vascular-related diseases.
Research in the LaConte lab is devoted to advanced neuroimaging acquisition and data analysis approaches, aimed at basic scientific discovery as well as understanding and rehabilitating neurological and psychiatric diseases. A major focus of the lab is an innovation in functional magnetic resonance imaging (fMRI) that we developed and call “temporally adaptive brain state” (TABS) fMRI.
We use complexity theory and network science to understand normal and abnormal brain function. Current projects: Developing new methods to generate functional brain networks. Effects of alcohol on brain networks Effects of obesity, weight loss, and exercise in the aging brain Brain health in farmworkers exposed to pesticides and nicotine.
Yong Woo Lee
The pro-oxidative and pro-inflammatory pathways have been implicated in various human chronic diseases including neurodegenerative and neuropsychiatric diseases. We investigate the critical role of oxidative stress and inflammation in 3 different experimental animal models of brain injury, such as (1) blast-induced neurotrauma (BINT), (2) radiation-induced cognitive impairment, and (3) autism spectrum disorders (ASD). Results from these studies will identify novel biomarkers in patients with brain disease that have the potential to offer new opportunities for diagnosis, prevention, and treatment.
We investigate how social distress causes mental disease. Using mouse models of social distress we study reorganization of neuronal connections in the prefrontal cortex and amygdala, the two brain structures implicated in fear and anxiety. Ex vivo electrophysiology combined with optogenetics are used to interrogate changes in specific neurons and synapses.
I am a translational biomedical engineer whose research focus is on studying the physiologic response to traumatic injuries. Specifically, my lab focuses on studying the pathophysiology of hemorrhagic shock, traumatic brain injury and resuscitation. This includes intense investigation of blood, saliva and urine-based biomarkers to help guide therapy to those with critical injuries and also developing targeted treatments for various injury types.
The Traumatic Nerve Technologies (TNT) lab conducts research in many diverse areas! We are taking a multidisciplinary approach to understanding nerve injuries, cell repair strategies and technologies that assist in prevention, identification and treatment of nervous tissue injuries. By advancing the fundamental understanding of the behavioral, morphologic, and molecular mechanistic repercussions accompanying traumatic injuries, we will further identify molecular targets and outcome measures needed for effective treatment strategies.
- Stephen LaConte, "Advanced Neuroimaging"
- Read Montague, "Human Neuroimaging and Computational Psychiatry"
- Konark Mukherjee, "Neurodevelopment"
- Brooks King-Casas, "Neural Basis of Valuation and Learning in Social Settings"
- Stefan Duma, "Concussion and Mild Traumatic Brain Injury"
- Warren Hardy, "Brain Trauma"
- Paul Laurienti, "Radiology"
- YongWoo Lee, "Pathophysiological Mechanisms of Neurological Disorders"
- Chris Wyatt, "System Identification and Classification in Neuroscience"
- Khalil Bitar, "Autologous Enteric Progenitor Cells (Enteric Neurospheres)"
- Joel Stitzel, "Imaging of brain Injury, Computational Modeling of TBI, Youth Football"
- Mark Van Dyke, "Peripheral Nerve and Spinal Cord Regeneration"
- John Rossmeisl, "Development of Imaging Modalities for Brain Tumor Detection"
- Youngkyoo Jung, "Acquisition, Reconstruction, and Analysis of Functional MRI"
- Alexei Morozov, “Functional Analysis of Neural Circuitry of Emotions”
- Satoru Hayasaka, "Analysis and Modeling of Human Brain Networks”
Advanced Neuroscience Imaging Research Core (ANSIR group)