Medical and biomedical imaging are disciplines necessary in virtually all fields of biomedical engineering. Developing technologies to visualize and model disease, injury, and even healthy tissue lie at the root of diagnosis and treatment.
Dr. Cao’s X-Ray Systems Lab aims at developing novel medical imaging technologies for biomedical and bioscientific discovery, radiological diagnosis, and medical intervention. The lab focuses on novel x-ray sources, detectors, and systems engineering. The research activities are interdisciplinary and translational, and interface between basic sciences, translational development, and clinical applications.
Measurement of heat transfer has wide-ranging applications in biomedical engineering -- from thermal comfort to blood perfusion. Several different non-invasive thermal methods for perfusion measurement have been developed. Applications are being developed for quantification of peripheral vascular disease, burn severity, pressure ulcers, wound healing, and melanoma detection.
I have a background in solid mechanics and mechanical engineering, which I have leveraged, in conjunction with my training as a biomedical engineer, to make advancements in the field of accelerative loading injury protection. My specific graduate training at VT&WFU revolved around the biomechanics of injury. While my strongest area is in computational biomechanics, my research encompasses projects touching on all aspects of civilian and military injury biomechanics, including projects in human model development and morphing, injury metric development, risk curve development, thermal burns and therapeutics, and the basic-science aspects of injury biomechanics.
We use complexity theory and network science to understand normal and abnormal brain function. Current projects: Developing new methods to generate functional brain networks. Effects of alcohol on brain networks Effects of obesity, weight loss, and exercise in the aging brain Brain health in farmworkers exposed to pesticides and nicotine.
We have identified a number of cardiac associated mutations and mapped out the effects on multiple molecular pathways. Yet, many patients with mutations are indistinguishable from genotypically “normal” patients until they die suddenly. We study a new electrical pathway by which cardiac cells communicate and conceal disease causing mutations. to treat vascular-related diseases.
Computational modeling of the human body, THUMS – Total Human Model for Safety, & GHBMC - Global Human Body Models Consortium. CIREN - Crash Injury Research and Engineering Network (CIREN). Anthropometry and modeling of real-world injuries. Advanced Automatic Crash Notification Algorithms utilizing hospital and crash databases for trauma triage. iTAKL – Imaging, Telemetry, and Kinematic Modeling of instrumented youth and high school football teams with medical imaging to understand biomechanics of subconcussive head impact. Human injury biomechanics, computational modeling of the human body, the relationship between computational model-based metrics and criteria and real-world injury and disease. Current support from industry & government: DOT, NASA, NSF (REU), DOD, NIH.
Injury biomechanics research focusing on the prevention, mitigation, and treatment of motor vehicle crash, military, and sporting injuries. Research interests include advanced automatic crash notification, human body and vehicle finite element modeling, and medical imaging analysis for anthropometry and bone quality characterization.
Development of theranostic agents for brain tumor diagnosis and treatment. Development of image-guided drug delivery system to cross the BBB to treat brain tumors.
- Chris Wyatt, "Medical Image Computing"
- Chang Lu, "Laser Induced Fluorescence Microscopy, TIRF-Based Technology"
- Debbie Kelly, "Cryo-Electron Microscopy"
- Lissett Bickford, "Design of Nanopharmaceuticals for Cancer Detection and Diagnosis"
- Craig Hamilton, "Cardiovascular Magnetic Resonance Imaging"
- Joel Stitzel, "Imaging and Anthropometry, Analysis of Injuries from CT and MRI"
- Guohua Cao, "Carbon Nanotube X-Ray Imaging"
- Shay Soker, "Imaging Technologies for Regenerative Medicine Applications"
- Youngkyoo Jung, "Acquisition, Reconstruction, and Analysis of Functional MRI"
- Michael Munley, "Radiation Dose Response Modeling for Advances Imaging for Therapy"
- Steve Poelzing, “Optical Mapping of Bioelectric Signals”
- Satoru Hayasaka, “Network Analyses of Brain Functional MRI Imaging Data”
- Steven Laconte, "MRI"
Advanced Neuroscience Imaging Research Core (ANSIR group)