Marissa Nichole Rylander, Ph.D.

Assistant Professor 
Department of Mechanical Engineering

335 ICTAS Building
Stanger Street (MC 0298)
Blacksburg, VA  24061

540-231-3134
540-231-0970 (fax)

mnr@vt.edu

http://www.me.vt.edu/nrylander/

EDUCATION:

• B.S., University of Texas-Austin, Mechanical Engineering, 2000

• M.S., University of Texas-Austin, Mechanical Engineering, 2002

• Ph.D., University of Texas-Austin, Biomedical Engineering, 2005

• Postdoctoral Fellow, University of Texas-Austin, Institute for Computational Engineering and Science, 2005-2006

RESEARCH INTERESTS:

• Thermal therapy design for cancer treatment and cardiac preconditioning

• Nanotechnology for therapeutics and diagnostics

• Measurement and imaging of cellular and tissue protein expression

• Bioheat transfer modeling

• Controlled angiogenesis and Heat Shock Protein (HSP) expression in tumors and tissue engineered constructs

TEACHING INTERESTS:

• Heat/Bioheat Transfer

• Thermal Therapy Design

RECENT PUBLICATIONS:

• M. N. Rylander, Y. Feng, Y. Zhang, J. Bass, R. J. Stafford, J. Hazle, and K. R. Diller, 2006, “Optimizing HSP Expression in Prostate Cancer Laser Therapy Through Predictive Computational Models,’ Journal of Biomedical Optics, 11:4,  04111131-16.
  Diller, K.R. and Rylander, M.N., Bioheat Transfer Phenomena Expressed Across Multiple Length Scales, Proceedings 13th International Heat Transfer Conference, Sydney, 2006, KN-03, 1-15.

• J. T. Oden, K. R. Diller, C. Bajaj, J. C. Browne, J. Hazle, I. Babuska, J. Bass, L. Demkowicz, Y. Feng, D. Fuentes, S. Prudhomme, M. N. Rylander, R. J. Stafford, and Y. Zhang, “Development of a Computational Paradigm for Laser Treatment of Cancer,” conference paper for 6th World Congress on Computational Mechanics, California, July, 2006, Lecture Notes in Computer Science, 3993, 530-537.

• Y. Feng, M. N. Rylander, J. Bass, J.T. Oden, and K. R.  Diller, “Optimal Design of Laser Surgery for Cancer Treatment Through Nanoparticle-Mediated Hyperthermia Therapy,” conference paper for National Cancer Institute - Special Symposium on Nanotechnology for Cancer Prevention, Diagnosis, and Treatment, California, May 2005, NSTI-Nanotech. 1, 39-42.

• M. N. Rylander, Y. Feng, J. Bass, and K. R. Diller, 2005, “Thermally Induced Injury and Heat-Shock Protein Expression in Cells and Tissues,” Annals of New York Academy of Science, 1066, 222-242.

• M. N. Rylander, S. Wang, S. Aggarwal, and K. R. Diller, 2005, “Correlation of HSP 70 Expression and Cell Viability Following Thermal Stimulation of Bovine Aortic Endothelial Cells,” Journal of Biomechanical Engineering, 127, 751-757.

• M. N. Rylander, Y. Feng, J. Bass, and K. R. Diller, 2006, “HSP Expression and Damage Optimization Algorithm for Prostate Cancer Therapy Design,” Lasers in Surgery and Medicine, In review.

• M. N. Rylander, Y. Feng, and K. R. Diller, 2006, “Thermally Induced HSP27, HSP60, and HSP70 Expression Kinetics and Cell Viability in Normal and Cancerous Prostate Cells,” The Prostate, In review.

• S Wang, W. Xie, M. N. Rylander, P. W. Tucker, S. Aggarwal, and K. R. Diller, 2006, “HSP70 Kinetics Study by Continuous Observation of HSP-GFP Fusion Protein Expression on a Perfusion Heating Stage,” Biotechnology and Bioengineering, In review.

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