Joseph W. Freeman, Ph.D.

Assistant Professor
Biomedical Engineering

327 ICTAS Building
Stanger Street (MC 0298)
Blacksburg, VA  24061

540-231-5686

jwfreeman@vt.edu

Musculoskeletal Tissue Regeneration Lab

EDUCATION:

• B.S.E., Princeton University, Chemical Engineering, 1997

• Ph.D., Rutgers University, Biomedical Engineering, 2003

RESEARCH INTERESTS:

• Tissue Engineering

• Molecular Modeling

• Biomechanics

• Biomaterials

RECENT PUBLICATIONS:

• J. W. Freeman, M. D. Woods, C. T. Laurencin, Tissue Engineering of the Anterior Cruciate Ligament Using a Braid-Twist Scaffold Design”, Journal of Biomechanics.  2007;40 (9):2029-2036

• W. J. Landis, F. H. Silver, J. W. Freeman, “Collagen as a scaffold for biomimetic mineralization of vertebrate tissues”, J. Mater. Chem., 2006, 16, 1495

• C. T. Laurencin, J. W. Freeman, “Ligament Tissue Engineering: An Evolutionary Materials Science Approach”, Biomaterials. 2005 Dec;26 (36):7530-6.

• F. H. Silver, J. W. Freeman, G.Bradica, “Structure and Function of Ligaments, Tendons and Joint Capsule”. Chapter 2, Orthopedic Biology and Medicine Series:  Repair and Regeneration of Ligaments, Tendon and Capsule , Humana Press, July 2005.

• J. W. Freeman, F. H. Silver, M. D. Woods, C. T. Laurencin, “The Role of Type I Collagen Molecular Structure in Tendon Elastic Energy Storage” Proceedings:  Material Research Society Spring Symposium, Materials Research Society, 2005.

• J. W. Freeman, F. H. Silver, “The Effects of Prestrain and Collagen Fibril Alignment on In Vitro Mineralization of Self-Assembled Collagen Fibers” Connect Tissue Res. 2005;46 (2):107-15.

• H. H. Lu, J. A. Cooper, S. Manuel, J. W. Freeman, M. A. Attawia, F. K. Ko, C. T. Laurencin, “Anterior Cruciate Ligament Regeneration Using Braided Biodegradable Scaffolds: In Vitro Optimization Studies”,  Biomaterials. 2005 Aug;26 (23):4805-16.

• J. A. Cooper, H. H. Lu, F. K. Ko, J. W. Freeman, C. T. Laurencin, “Fiber-based tissue-engineered scaffold for ligament replacement: design considerations and in vitro evaluation”,  Biomaterials. 2005 May; 26 (13):1523-32.

• J. W. Freeman, F. H. Silver, “Analysis Of Mineral Deposition In Turkey Tendons And Self-Assembled Collagen Fibers Using Mechanical Techniques” Connect Tissue Res. 2004;45 (3):131-41.

• J. W. Freeman, F. H. Silver, “Elastic energy storage in unmineralized and mineralized extracellular matrices (ECMs): a comparison between molecular modeling and experimental measurements”, J Theor Biol. 2004 Aug 7; 229 (3):371-81.

• F. H. Silver, J. W. Freeman, and G. P. Seehra, "Collagen Self Assembly and the Development of Tendon Mechanical Properties", Journal of Biomechanics 2003 Oct; 36 (10): 1529-1553.

• F. H. Silver, J. W. Freeman, I. Horvath, and G.Bradica, “The Role of Collagen in Energy Storage and Dissipation in ECM” Proceedings: Protein-based Nanotechnology Satellite Meeting, 47th Annual Meeting, Biophysical Society, 2003.

• F. H. Silver, G. P, Seehra, and J. W. Freeman, and D. DeVore, “Viscoelastic Properties of Young and Old Human Dermis:  A Proposed Molecular Mechanism for Elastic Energy Storage in Collagen and Elastin." Journal of Applied Polymer Science 2002 Nov, 86 (8): 1978-85.

• F. H. Silver, J. W. Freeman, I. Horvath, and W. J. Landis, "Molecular Basis for Elastic Energy Storage In Mineralized Tendon", Biomacromolecules 2001 Sept; 2 (1): 750-756.

• F. H. Silver, J. W. Freeman, and D. DeVore, "Viscoelastic Properties of Human Skin and Processed Dermis", Skin Res Technol. 2001 Feb; 7 (1):18-23.

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