Rafael V. Davalos, Ph.D.

Assistant Professor
Biomedical Engineering

329 ICTAS Building
Stanger Street (MC 0298)
Blacksburg, VA  24061

540-231-1979
540-541-8320 (fax)

davalos@vt.edu

EDUCATION:

• Ph.D., University of California – Berkeley; Bioengineering

• M.S., University of California – Berkeley; Mechanical Engineering

• B.S., Cornell University -  Mechanical and Aerospace Engineering

RESEARCH INTERESTS:

• Biomedical microdevices

• Irreversible electroporation

• Dielectrophoretic cell manipulation

• Image-guided surgery

• Single cell analysis

• Cancer detection and treatment

RECENT PUBLICATIONS:

• JF Edd, RV Davalos. Mathematical modeling of irreversible   electroporation for treatment planning. Technology in Cancer  Research and Treatment, v6:275-286, 2007.

• RV Davalos, GJ McGraw, TI Wallow, AM Morales, KL Krafcik, GJ Fiechtner, Y Fintschenko, EB Cummings, BA Simmons. The application of insulator-based dielectrophoresis polymer  microfluidic devices as particle separators and the impact of dynamic surface coatings on performance.  Analytical and        Bioanalytical Chemistry, v389:1426-1425, 2007.

• R.V. Davalos, Y. Huang and B. Rubinsky, "Electroporation: bio-electrochemical mass transfer at the nano scale," Microscale Thermophysical Engineering, vol. 4, pp. 147-159, 2000.

• R.V. Davalos, D.M. Otten and B. Rubinsky, "A feasibility study for electrical impedance tomography as a means to monitor tissue electroporation for molecular medicine," IEEE Transactions on Biomedical Engineering, vol. 49(4), pp. 400-403, 2002.

• R.V. Davalos, B. Rubinsky and L.M. Mir, "Theoretical analysis of the thermal effects during in vivo tissue electroporation,"
  Bioelectrochemistry, vol. 61(1-2), pp. 99-107, 2003.

• R.V. Davalos and B. Rubinsky, "Electrical impedance tomography of cell viability in tissue with application to cryosurgery," Journal of Biomechanical Engineering, vol. 126(2), pp. 305-309, 2004.

• R.V. Davalos, B.H. Lapizco-Encinas, G.J. Fiechtner, A.K. Singh, B.A. Simmons, Y. Fintschenko and E.B. Cummings, "A performance comparison of post- and ridge-based dielectrophoretic particle sorters," Royal Society of Chemical Special Publications, 8th International Conference on Miniaturized Systems for Chemistry and Life Sciences, Malmo, Sweden, Sep 26-30, no. 296, pp. 650-652, 2004.

• R.V. Davalos, D.M. Otten, L.M. Mir and B. Rubinsky, "Electrical impedance tomography for imaging tissue electroporation," IEEE Transactions on Biomedical Engineering, vol. 51(5) pp. 761-767, 2004.

• R.V. Davalos, L.M. Mir and B. Rubinsky, "Tissue ablation with irreversible electroporation," Annals of Biomedical Engineering, vol.
  33(2), pp. 223-231, 2005.

• R.G. Guerra, R.V. Davalos, P.A. Garcia, B. Rubinsky and M.S. Berger, "A heat transfer model to characterize the focal cooling necessary to suppress spontaneous Epileptiform activity," SPIE Proceedings: PW05B Biomedical Optics - Thermal Treatment of Tissue: Energy Delivery and Assessment VI, San Jose, CA, Jan 25-27, vol. 5698(23), pp. 240-246, 2005.

• B.H. Lapizco-Encinas, R.V. Davalos, B.A. Simmons, E.B. Cummings and Y. Fintschenko, "An insulator-based (electrodeless) dielectrophoretic concentrator for microbes in water," Journal of Microbiological Methods, vol. 62, pp. 317-326, 2005.

• G.J. McGraw, R.V. Davalos, B.M. Mittal, S.M. Ferko, M.C. Hunter, J.D. Brazzle, Y. Fintschenko, E.B. Cummings and B.A. Simmons, "Scalability of insulator-based dielectrophoresis (iDEP) and its utilization as a high-throughput particle concentrator," Royal Society of Chemical Special Publications, 9th International Conference on Miniaturized Systems for Chemistry and Life Sciences , Boston, MA, Oct 9-13, pp. 705-708, 2005.

• M. Khine, A. Lau, C.I. Zanetti, J. Seo, E.S. Lee, R.V. Davalos and L.P. Lee, "A low-voltage single cell electroporation array for intracellular compound delivery," Royal Society of Chemical Special Publications, 9th International Conference on Miniaturized Systems for Chemistry and Life Sciences, Boston, MA, Oct 9-13, pp. 856-858, 2005.

• B.A. Simmons, G.J. McGraw, R.V. Davalos , G.J. Fiechtner, Y. Fintschenko and E.B. Cummings, "Development of polymeric devices as dielectrophoretic separators and concentrators," MRS Bulletin , vol. 31, pp. 120-124, 2006.

• E.S. Lee, D. Robinson, J.L. Rognlien, C.K. Harnett, B.A. Simmons, C.R.B. Ellis and R.V. Davalos, " Robust giant lipid vesicles and micro-electroporation technology for controllable manipulation of picoliter volumes on-chip," Bioelectrochemistry, vol. 69, pp. 117-125, 2006.

• P. Ponce, B.A. Simmons, M. Khine, and R. V. Davalos, " A bioparticle detector using integrated insulator-based dielectrophoresis and bioimpedance measurements," Royal Society of Chemical Special Publications, 10th International Conference on Miniaturized Systems for Chemistry and Life Sciences , Tokyo, Japan, Nov 5-9, pp. 987-989, 2006.

• E.S. Lee, S.S. Bachelor, Z.Q. Iqbal, L.P. Lee and R.V. Davalos, "Viability after on-chip single-cell micro-electroporation for the study of macrophage signaling pathways," Royal Society of Chemical Special Publications, 10th International Conference on Miniaturized Systems for Chemistry and Life Sciences , Tokyo, Japan, Nov 5-9, pp. 1345-1347, 2006.

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