Joel Berry, Ph.D

Research Assistant Professor 
Department of Biomedical Engineering

Wake Forest University Health Sciences 
Medical Center Blvd. 
Winston-Salem, NC 27157-1022



Phone:  336-716-5057
E-mail: jberry@wfubmc.edu


EDUCATION:

	B.S., Biology, Mechanical Engineering, The University of Alabama at Birmingham
	M.S., Mechanical Engineering,  The University of Alabama at Birmingham
	Ph.D., Medical Engineering, Wake Forest University School of Medicine

RESEARCH INTERESTS:

	Vascular Stents: We have been investigating the fluid mechanical and solid mechanical consequences of vascular stenting. In vitro measurement tools such as dye injection visualization and digital particle image velocimetry reveal disturbances in physiologic flow that may lead to thrombotic responses in stents. This has been confirmed with computational fluid dynamic analyses. Finite element analyses has shown that stents elevate vessel wall stress significantly beyond physiologic stress. This excessively high stress that is cycled at every heartbeat may lead to tissue proliferation within the stent. Several stent designs have been proposed by our laboratory to alleviate this effect. Preliminary in vivo studies in our laboratory have demonstrated that matching the compliance at the junction of stented and unstented vessel has the effect of minimizing the vessel response compared to non-compliance matched stents.
	Platelet attachment force to surfaces: We have used atomic force microscopy to measure the force of platelet attachment to biological surfaces in aqueous solution. Ongoing studies in our collaborating laboratories will demonstrate that platelets bind to different surfaces with different binding affinities. Of particular interest is the platelet binding force to anti-adhesins.
	Development of Recombinant DNA Anti-Adhesins: We are currently testing a recombinant DNA variant of the plasma protein vitronectin as an anti-adhesive protein coating for implantable vascular devices. Preliminary results have shown this protein to be highly adherent to metallic surfaces and extremely effective at limiting thrombus formation on stents as well reducing neointimal hyperplasia.
	Development of Bioengineered Arterial Grafts: We are currently collaborating with the Wake Forest Institute for Regenerative Medicine to develop efficient bioreactors to precondition cell-seeded arterial scaffolds before implantation.

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RECENT PUBLICATIONS:

	Berry JL (Division of Radiologic Sciences--Department of Biomedical Engineering), Yazdani SK (Division of Radiologic Sciences--Department of Biomedical Engineering):    Vessel wall stress created by thin strut versus thick strut stents [abstract]. Am J Cardiol 2004;94(6A Suppl):156E.
	Rolland PH, Mekkaoui C, Vidal V, Berry JL (Division of Radiologic Sciences--Department of Biomedical Engineering), Moore JE, Moreno M, Amabile P, Bartoli JM:  Compliance matching stent placement in the carotid artery of the swine promotes optimal blood flow and attenuates restenosis. Eur J Vasc Endovasc Surg 2004;28(4):431-438.
	Yazdani SK (Division of Radiologic Sciences--Department of Biomedical Engineering), Moore JE Jr, Berry JL (Division of Radiologic Sciences--Department of Biomedical Engineering), Vlachos PP:    DPIV measurements of flow disturbances in stented artery models: adverse affects [sic] of compliance mismatch. J Biomech Eng 2004;126(5):559-566.
	Berry J (Division of Radiologic Sciences--Department of Biomedical Engineering), Moore JE:     Compliant intraluminal stents [patent]. Wake Forest University Health Sciences, assignee; US patent 6,572,649; 2003 June 3;:.
	Deliargyris EN (Department of Internal Medicine--Section on Cardiology), Berry JL (Division of Radiologic Sciences--Department of Biomedical Engineering), Rolland PH, Mekkaoui C, Moore JE:   A novel compliance matching design improves the hemodynamic and mechanical disturbances associated with stenting [abstract]. Am J Cardiol 2003;92(Suppl 6A):216L-217L.
	Berry JL (Division of Radiologic Sciences--Department of Medical Engineering), Manoach E, Mekkaoui C, Rolland PH, Moore JE Jr, Rachev A:   Hemodynamics and wall mechanics of a compliance matching stent: in vitro and in vivo analysis. J Vasc Interv Radiol 2002;13(1):97-105.
	Moore J Jr, Berry JL (Division of Radiologic Sciences--Department of Biomedical Engineering):     Fluid and solid mechanical implications of vascular stenting. Ann Biomed Eng 2002;30(4):498-508.
	Berry JL (Division of Radiologic Sciences--Department of Medical Engineering):     Compliant interluminal stents [patent]. Wake Forest University Health Sciences, assignee; US patent 6,206,910; 2001 Mar 27;:.
	Berry J (Division of Radiologic Sciences--Department of Medical Engineering), Ferrario CM (Division of Surgical Sciences--Department of General Surgery), Dean RH (Division of Surgical Sciences--Department of General Surgery): Expandable intraluminal stents [patent]. Wake Forest University Health Sciences, assignee; US patent 6,248,128; 2001 June 19.