VT-WFU School of Biomedical Engineering and Sciences

Joseph A. Maldjian, M.D.

Professor of Radiologic Sciences – Radiology
Radiologic Sciences – Medical Engineering

Director, Advanced Neuroscience Imaging Research Lab (ANSIR)
Chairman, Magnetic Resonance Imaging Committee,
Center for Biomolecular Imaging

Department of Radiology
Division of Radiologic Sciences
Wake Forest University School of Medicine
Medical Center Boulevard
Winston-Salem, North Carolina 27157-1088

336-716-2815
maldjian@wfubmc.edu

EDUCATION:

B.A., Biochemistry, Princeton University

M.D., UMDNJ, New Jersey medical School

RESEARCH INTERESTS:

Dr. Maldjian is a neuroradiologist with expertise in interpretation of all neuroimaging modalities, as well as extensive experience in software development for a variety of neuroimaging processing applications. His research interests include advanced MRI applications in the CNS for research and clinical applications; Diffusion MRI; Functional MRI (fMRI); Perfusion MRI.

Dr. Maldjian has been involved in functional MRI studies since the inception of this technology in the early 1990’s and is regarded as a leading investigator in neurosurgical applications of fMRI. He has established successful functional MRI labs at several institutions including the Hospital of the University of Pennsylvania, UMDNJ-New Jersey Medical School, and most recently at Wake Forest University Baptist Medical Center where he is currently Associate Professor of Radiology and Director of the Advanced Neuroscience Imaging Research Laboratory.

He is fluent in IDL, MATLAB, C, UNIX shell programming, in addition to some pulse programming experience for the General Electric (GE) LX MR platform. He has been involved in developing interfaces between real-time neurosurgical workstations and functional MRI for several years and has published several articles validating fMRI against intraoperative mapping using these interfaces.

He has demonstrated expertise in multimodal image software development, having integrated CT scan data into the IDLSPM processing environment and has developed methods for forward and backward DICOM conversion of image data. He has detailed knowledge of the GE MR systems and has developed methodologies for real-time archival of raw data, interrogation of the GE online magnet database, and methods for interfacing offline fMRI data to PACS.

RECENT PUBLICATIONS:

Maldjian JA. Basic principles of functional MRI, In Practical Reviews in Radiology, Baker S. (ed), 1995.

Maldjian JA, Patel RS. Cerebral Neoplasms in Adults, Seminars in Roentgenology 1999, Elsevier Press, 34(2), 102-122.

McGarvey ML, Ferrante FM, Patel RS, Maldjian JA, Stecker M. Irreversible spinal cord injury as a complication of subarchnoid ethanol neurolysis. Neurology 2000, 54:1522-1524.

Maldjian C, Adam R, Rudelli R, Maldjian JA, Chew Q, Bonakdarpour A. Elastofibroma of the neck. Skeletal Radiol 2000; 29:109-111.

Holodny AI, Schulder M, Liu WC, Wolko J, Maldjian JA, Kalnin AJ. The effect of brain tumors on BOLD fMRI activation in the adjacent motor cortex: implications for image-guided neurosurgery. AJNR Am J Neuroradiol 2000; 21:1415-1422.

Chalela JA, Alsop DC, Gonzalez-Atavalez JB, Maldjian JA, Kasner SE, Detre JA. Magnetic resonance perfusion imaging in acute ischemic stroke using continuous arterial spin labeling. Stroke 2000; 31:680-687.

Levy-Reis I, Casasanto D, French JA, Alsop DA, Maldjian JA, Gonzalez-Atavalez JB, Detre JA. Absence of function and cortical reorganization in nevus linear subaceous syndrome (NLSS). J Neuroimaging 2000; 10(4): 225-228.

Roychowdhury S, Maldjian JA, Grossman RI. Multiple sclerosis: comparison of trace apparent diffusion coefficients with MR enhancement pattern of lesions. AJNR Am J Neuroradiol 2000; 21:869-874.

Gur RC, Alsop D, Glahn D, Petty R, Swanson CL, Maldjian JA, Turetsky BI, Detre JA, Gee J, Gur RE. An fMRI study of sex differences in regional activation to a verbal and a spatial task. Brain Lang 2000; 74:157-170.

Maldjian JA, Listerud J. Automated teaching file/slide database for digital images. AJR Am J Roentgenol 2000; 175:1249-1251.

Killgore WDS, Casasanto DJ,Yurglin-Todd D, Maldjian JA, Detre JA. Functional Activation of the Left Amygdala and Hippocampus during Associative Encoding of Faces. Neuroreport 2000, 11(10), 2259-2263.

Patel, RS, Yousem DM, Maldjian JA, Zager EL. Incidence and clinical significance of frontal sinus or orbit entry during pterional (front temporal) craniotomy. AJNR Am J Neuroradiol 2000, 21:1327-1330.

Maldjian, JA, Burdette JH. Neuroimaging expands with functional MRI. Diagnostic Imaging December 2001; Advanced MR Supplement.

Maldjian JA, Grossman RI. Future Applications of DWI in MS. JNS 186 (2001) S55-S57

Maldjian JA, Listerud J, Moonis G, Siddiqi F. Computing diffusion rates in T2-dark hematomas and areas of low T2 signal. AJNR Am J Neuroradiol 2001, 22:112-118.

Maldjian JA, Detre JA, Killgore WDS, Judy K, Alsop D, Grossman M, Glosser G. Neuropsychologic performance following resection of an activation cluster involved in cognitive memory function. AJR Am J Roentgenol 2001: 176:541-544.

Chalela JA, Wolf RL, Maldjian JA, Kasner SE. MRI Identification of Early White Matter Injury In Anoxic-Ischemic Encephalopathy. Neurology 2001; 56(4):481-485.

Maldjian JA, Chalela J, Kasner SE, Liebeskind D, Detre JA. Automated CT segmentation and analysis for acute MCA stroke. AJNR Am J Neuroradiol 2001; 22(6):1050-1055.

Wolf RL, Alsop DC, Levy-Reis I, Meyer PT, Maldjian JA, Gonzalez-Atavales J, French JA, Alavi A, Detre JA. Detection of mesial temporal lobe hypoperfusion in patients with temporal lobe epilepsy by use of arterial spin labeled perfusion MR imaging. AJNR Am J Neuroradiol 2001; 22:1334-1341.

Chepuri NB, Yen Y-F, Burdette JH, Li H, Moody DM, Maldjian JA. Diffusion anisotropy in the corpus callosum. AJNR Am J Neuroradiol 2002; 23:803-808.

Maldjian JA, Laurienti PJ, Driskill L, Burdette JH. Multiple reproducibility indices for evaluation of cognitive functional MR imaging paradigms. AJNR Am J Neuroradiol 2002; 23:1030-1037.

Laurienti PJ, Field AS, Burdette JH, Maldjian JA, Yen Y-F, Moody DM. Dietary caffeine consumption modulates fMRI measures. NeuroImage 2002; 17:751-757.

Maldjian JA, Listerud J, Khalsa S. Integrating post-processed functional MR images with picture archiving and communication systems. AJNR Am J Neuroradiol 2002; 23:1393-1397.

Franklin TR, Acton PD, Maldjian JA, Gray JD, Croft JR, Dackis CA, O’Brien CP, Childress AR. Decreased gray matter concentration in the insular, orbitofrontal, cingulated and temporal cortices of cocaine patients. Biol Psychiatry 2002; 51:134-142.

Langleben DD, Schroeder L, Maldjian JA, Gur RC, McDonald S, Ragland JD, O’Brien CP, Childress AR. Brain activity during simulated deception: an event-related functional magnetic resonance study. Neuroimage 2002; 15:727-732.

Casasanto DJ, Killgore WDS, Maldjian JA, Glosser G, Alsop DC, Cooke AM, Grossman M, Detre JA. Neural correlates of successful and unsuccessful verbal memory encoding. Brain Lang 2002; 80:287-295.

Gur RC, Schroeder L, Turner T, McGrath C, Chan RM, Turetsky BI, Alsop D, Maldjian JA, Gur RE. Brain activation during facial emotion processing. NeuroImage 2002; 16(3 Pt 1):651-662.

Gur RE, McGrath C, Chan RM, Schroeder L, Turner T, Turetsky BI, Kohler C, Alsop D, Maldjian JA, Ragland JD, Gur RC. An fMRI study of facial emotion processing in schizophrenia. Am J Psychiatry 2002; 159:1992-1999.

Gunning-dixon FM, Gur RC, Perkins AC, Schroeder L, Turner T, Turetsky BI, chan RM, Loughead JW, Alsop DC, Maldjian JA, Gur RE. Age-related differences in brain activation during emotional face processing. Neurobiol Aging 2003; 24:285-295.

Laurienti PJ, Wallace MT, Maldjian JA, Susi CM, Stein BE, Burdette JH. Cross-modal sensory processing in the anterior cingulated and medial prefrontal cortices. Hum Brain Mapping 2003; 19:213-223.

Wolf RL, Alsop DC, McGarvey ML, Maldjian JA, Wang J, Detre JA. Susceptibility contrast and arterial spin labeled perfusion MRI in cerebrovascular disease. J Neuroimaging 2003; 13:17-27.

Laurienti PJ, Field AS, Burdette JH, Maldjian JA, Yen Y-F, Moody DM. Relationship between caffeine-induced changes in resting cerebral perfusion and blood oxygenation level-dependent signal. AJNR Am J Neuroradiol 2003; 24:1607-1611.

Maldjian JA, Laurienti PJ, Burdette JH, Kraft RA. An automated method for neuroanatomic and cytoarchitectonic atlas-based interrogation of fMRI data sets. NeuroImage 2003; 19:1233-1239.

Laurienti PJ, Burdette JH, Maldjian JA. Separating neural processes using mixed event-related and epoch-based fMRI paradigms. J Neurosci Methods 2003; 131:41-50.

Wang J, Alsop DC, Song HK, Maldjian JA, Tang K, Salvucci AE, Detre JA. Arterial transit time imaging with flow encoding arterial spin tagging (FEAST). Magn Reson Med 2003; 50:599-607.

Maldjian JA, Listerud J, Khalsa S. Integrating Post-Processed functional MR Images with PACS. AJNR 2002: 23: 1393-97.

Maldjian JA, Laurienti PJ, Burdette JH. Precentral gyrus discrepancy in electronic versions of the Talairach atlas. NeuroImage 2004; 21:450-455.

Ances BM, McGarvey ML, Abrahams JM, Maldjian JA, Alsop DC, Zager EL, Detre JA. Continuous arterial spin labeled perfusion magnetic resonance imaging in patients before and after carotid endarterectomy. J Neuroimaging. 2004 Apr;14(2):133-8.

Laurienti PJ, Kraft RA, Maldjian JA, Burdette JH, Wallace MT. Semantic congruence is a critical factor in multisensory behavioral performance. Exp Brain Res 2004. Jun 18.

Laurienti PJ, Kraft RA, Maldjian JA, Burdette JH, Wallace MT. Semantic congruence is a critical factor in multisensory behavioral performance. Exp Brain Res 2004; 158:405-414.

Laurienti PJ, Burdette JH, Maldjian JA, Wallace MT. Enhanced Multisensory Integration in Older Adults. Neurobiology of Aging. 2006 Aug: 27(8): 1155-63.

Ryali S, Casanova R, Baer A, Laurienti PJ, Burdette JH, Hayasaka S, Flowers F, Wood J, Maldjian JA. Biological Parametric Mapping: A Statistical Toolbox for Multi-Modality Brain Image Analysis. Neuroimage 2006, (Epub ahead of print)

Casanova R, Ryali S, Laurienti PJ, Peiffer AM, Maldjian JA. Estimation of False Discovery Rates for Wavelet-Denoised Statistical Parametric Maps. Neuroimage 2006, Aug 15: (Epub ahead of print)

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> Brown, Gary

> Buehrer, Michael

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> Carr, J. Jeffrey

> Carroll, David

> Chatterjee, Arjun

> Christ, George

> Dahlgren, Linda

> Davis, William

> Davy, Kevin

> Diller, Thomas

> Eng, Ludeman

> Ferguson, Cristine

> Fetrow, Jacquelyn

> Gage, Donald

> Goulbourne, Nakhiah

> Grange, Robert

> Hampton, Carnell

> Harrison, Benjamin

> Heath, Lenwood

> Herrington, David

> Holzwarth, George

> Huckle, William

> Hundley, William

> Inzana, Thomas

> Jones, Jeryl

> Jortner, Bernard

> Kim-Shapiro, Daniel

> Kremkau , Frederic

> Lanz, Otto

> Laubenbackher, Reinhard

> Laurienti, Paul

> Lazar, Iuliana

> Lee, Sang Jin

> Li, Liwu

> Link, Kerry

> Maldjian, Joseph

> Marsh, Anthony

> Meehan, Kathleen

> Moore, David

> Morykwas, Michael

> Ohanehi, Donatus

> Paul, Mark

> Plaut, Raymond

> Quek, Francis

> Robertson, John

> Ross, Shane

> Rubin, Bruce

> Rzigalinski, Beverly

> Schurig, Gerhardt

> Smith, Thomas

> Soker, Shay

> Sturges, Robert

> Suzuki, Yasuhiro

> Tafti, Danesh

> Tanaka, Martin

> Tyson, Reid

> Watson, Layne

> Wiesler, Ethan

> Yoo, James

> Zhang, Chenming

Joseph A. Maldjian, M.D. Professor of Radiologic Sciences – Radiology Radiologic Sciences – Medical Engineering Director, Advanced Neuroscience Imaging Research Lab (ANSIR) Chairman, Magnetic Resonance Imaging Committee, Center for Biomolecular Imaging

Department of Radiology Division of Radiologic Sciences Wake Forest University School of Medicine Medical Center Boulevard Winston-Salem, North Carolina 27157-1088 336-716-2815 maldjian@wfubmc.edu

EDUCATION:

B.A., Biochemistry, Princeton University

M.D., UMDNJ, New Jersey medical School

RESEARCH INTERESTS:

RECENT PUBLICATIONS:

Holodny AI, Schulder M, Liu WC, Wolko J, Maldjian JA, Kalnin AJ. The effect of brain tumors on BOLD fMRI activation in the adjacent motor cortex: implications for image-guided neurosurgery. AJNR Am J Neuroradiol 2000; 21:1415-1422.

Chalela JA, Alsop DC, Gonzalez-Atavalez JB, Maldjian JA, Kasner SE, Detre JA. Magnetic resonance perfusion imaging in acute ischemic stroke using continuous arterial spin labeling. Stroke 2000; 31:680-687.

Levy-Reis I, Casasanto D, French JA, Alsop DA, Maldjian JA, Gonzalez-Atavalez JB, Detre JA. Absence of function and cortical reorganization in nevus linear subaceous syndrome (NLSS). J Neuroimaging 2000; 10(4): 225-228.

Roychowdhury S, Maldjian JA, Grossman RI. Multiple sclerosis: comparison of trace apparent diffusion coefficients with MR enhancement pattern of lesions. AJNR Am J Neuroradiol 2000; 21:869-874.

Gur RC, Alsop D, Glahn D, Petty R, Swanson CL, Maldjian JA, Turetsky BI, Detre JA, Gee J, Gur RE. An fMRI study of sex differences in regional activation to a verbal and a spatial task. Brain Lang 2000; 74:157-170.

Maldjian JA, Listerud J. Automated teaching file/slide database for digital images. AJR Am J Roentgenol 2000; 175:1249-1251.

Killgore WDS, Casasanto DJ,Yurglin-Todd D, Maldjian JA, Detre JA. Functional Activation of the Left Amygdala and Hippocampus during Associative Encoding of Faces. Neuroreport 2000, 11(10), 2259-2263.

Patel, RS, Yousem DM, Maldjian JA, Zager EL. Incidence and clinical significance of frontal sinus or orbit entry during pterional (front temporal) craniotomy. AJNR Am J Neuroradiol 2000, 21:1327-1330.

Maldjian, JA, Burdette JH. Neuroimaging expands with functional MRI. Diagnostic Imaging December 2001; Advanced MR Supplement.

Maldjian JA, Grossman RI. Future Applications of DWI in MS. JNS 186 (2001) S55-S57

Maldjian JA, Listerud J, Moonis G, Siddiqi F. Computing diffusion rates in T2-dark hematomas and areas of low T2 signal. AJNR Am J Neuroradiol 2001, 22:112-118.

Maldjian JA, Detre JA, Killgore WDS, Judy K, Alsop D, Grossman M, Glosser G. Neuropsychologic performance following resection of an activation cluster involved in cognitive memory function. AJR Am J Roentgenol 2001: 176:541-544.

Chalela JA, Wolf RL, Maldjian JA, Kasner SE. MRI Identification of Early White Matter Injury In Anoxic-Ischemic Encephalopathy. Neurology 2001; 56(4):481-485.

Maldjian JA, Chalela J, Kasner SE, Liebeskind D, Detre JA. Automated CT segmentation and analysis for acute MCA stroke. AJNR Am J Neuroradiol 2001; 22(6):1050-1055.

Wolf RL, Alsop DC, Levy-Reis I, Meyer PT, Maldjian JA, Gonzalez-Atavales J, French JA, Alavi A, Detre JA. Detection of mesial temporal lobe hypoperfusion in patients with temporal lobe epilepsy by use of arterial spin labeled perfusion MR imaging. AJNR Am J Neuroradiol 2001; 22:1334-1341.

Chepuri NB, Yen Y-F, Burdette JH, Li H, Moody DM, Maldjian JA. Diffusion anisotropy in the corpus callosum. AJNR Am J Neuroradiol 2002; 23:803-808.

Maldjian JA, Laurienti PJ, Driskill L, Burdette JH. Multiple reproducibility indices for evaluation of cognitive functional MR imaging paradigms. AJNR Am J Neuroradiol 2002; 23:1030-1037.

Laurienti PJ, Field AS, Burdette JH, Maldjian JA, Yen Y-F, Moody DM. Dietary caffeine consumption modulates fMRI measures. NeuroImage 2002; 17:751-757.

Maldjian JA, Listerud J, Khalsa S. Integrating post-processed functional MR images with picture archiving and communication systems. AJNR Am J Neuroradiol 2002; 23:1393-1397.

Franklin TR, Acton PD, Maldjian JA, Gray JD, Croft JR, Dackis CA, O’Brien CP, Childress AR. Decreased gray matter concentration in the insular, orbitofrontal, cingulated and temporal cortices of cocaine patients. Biol Psychiatry 2002; 51:134-142.

Langleben DD, Schroeder L, Maldjian JA, Gur RC, McDonald S, Ragland JD, O’Brien CP, Childress AR. Brain activity during simulated deception: an event-related functional magnetic resonance study. Neuroimage 2002; 15:727-732.

Casasanto DJ, Killgore WDS, Maldjian JA, Glosser G, Alsop DC, Cooke AM, Grossman M, Detre JA. Neural correlates of successful and unsuccessful verbal memory encoding. Brain Lang 2002; 80:287-295.

Gur RC, Schroeder L, Turner T, McGrath C, Chan RM, Turetsky BI, Alsop D, Maldjian JA, Gur RE. Brain activation during facial emotion processing. NeuroImage 2002; 16(3 Pt 1):651-662.

Gur RE, McGrath C, Chan RM, Schroeder L, Turner T, Turetsky BI, Kohler C, Alsop D, Maldjian JA, Ragland JD, Gur RC. An fMRI study of facial emotion processing in schizophrenia. Am J Psychiatry 2002; 159:1992-1999.

Gunning-dixon FM, Gur RC, Perkins AC, Schroeder L, Turner T, Turetsky BI, chan RM, Loughead JW, Alsop DC, Maldjian JA, Gur RE. Age-related differences in brain activation during emotional face processing. Neurobiol Aging 2003; 24:285-295.

Laurienti PJ, Wallace MT, Maldjian JA, Susi CM, Stein BE, Burdette JH. Cross-modal sensory processing in the anterior cingulated and medial prefrontal cortices. Hum Brain Mapping 2003; 19:213-223.

Wolf RL, Alsop DC, McGarvey ML, Maldjian JA, Wang J, Detre JA. Susceptibility contrast and arterial spin labeled perfusion MRI in cerebrovascular disease. J Neuroimaging 2003; 13:17-27.

Laurienti PJ, Field AS, Burdette JH, Maldjian JA, Yen Y-F, Moody DM. Relationship between caffeine-induced changes in resting cerebral perfusion and blood oxygenation level-dependent signal. AJNR Am J Neuroradiol 2003; 24:1607-1611.

Maldjian JA, Laurienti PJ, Burdette JH, Kraft RA. An automated method for neuroanatomic and cytoarchitectonic atlas-based interrogation of fMRI data sets. NeuroImage 2003; 19:1233-1239.

Laurienti PJ, Burdette JH, Maldjian JA. Separating neural processes using mixed event-related and epoch-based fMRI paradigms. J Neurosci Methods 2003; 131:41-50.

Wang J, Alsop DC, Song HK, Maldjian JA, Tang K, Salvucci AE, Detre JA. Arterial transit time imaging with flow encoding arterial spin tagging (FEAST). Magn Reson Med 2003; 50:599-607.

Maldjian JA, Listerud J, Khalsa S. Integrating Post-Processed functional MR Images with PACS. AJNR 2002: 23: 1393-97.

Maldjian JA, Laurienti PJ, Burdette JH. Precentral gyrus discrepancy in electronic versions of the Talairach atlas. NeuroImage 2004; 21:450-455.

Ances BM, McGarvey ML, Abrahams JM, Maldjian JA, Alsop DC, Zager EL, Detre JA. Continuous arterial spin labeled perfusion magnetic resonance imaging in patients before and after carotid endarterectomy. J Neuroimaging. 2004 Apr;14(2):133-8.

Laurienti PJ, Kraft RA, Maldjian JA, Burdette JH, Wallace MT. Semantic congruence is a critical factor in multisensory behavioral performance. Exp Brain Res 2004. Jun 18.

Laurienti PJ, Kraft RA, Maldjian JA, Burdette JH, Wallace MT. Semantic congruence is a critical factor in multisensory behavioral performance. Exp Brain Res 2004; 158:405-414.

Laurienti PJ, Burdette JH, Maldjian JA, Wallace MT. Enhanced Multisensory Integration in Older Adults. Neurobiology of Aging. 2006 Aug: 27(8): 1155-63.

Ryali S, Casanova R, Baer A, Laurienti PJ, Burdette JH, Hayasaka S, Flowers F, Wood J, Maldjian JA. Biological Parametric Mapping: A Statistical Toolbox for Multi-Modality Brain Image Analysis. Neuroimage 2006, (Epub ahead of print)

Casanova R, Ryali S, Laurienti PJ, Peiffer AM, Maldjian JA. Estimation of False Discovery Rates for Wavelet-Denoised Statistical Parametric Maps. Neuroimage 2006, Aug 15: (Epub ahead of print)