Liwu Li, Ph.D

Associate Professor
Department of Biology
Program in Inflamation

206 Fralin Biotechnology Center
Blacksburg, VA 24061

Phone: 540-231-1433
Fax: 540-231-2317

E-mail:lwli@vt.edu

http://www.biol.vt.edu/faculty/li/

EDUCATION:

	Ph.D, Cell & Mol Biol., University of Michigan, 1996
	Post-doc, Biochemistry, University of Michigan, 1999

RESEARCH INTERESTS:

	Cellular and molecular signaling events controlling innate immunity
	Innate immunity and the pathogenesis of atherosclerosis
	Innate immunity and cancer
	Innate immunity and host defense against infection
	Chemical and Biochemical intervention of innate immunity signaling

RECENT PUBLICATIONS:

	Xie Q, Gan L, Wang J, Wilson I, Li L. (2007) Loss of the innate immunity negative regulator IRAK-M leads to enhanced host immune defense against tumor growth. Mol Immunol. 44:3453-3461.
	Su J, Richter K, Zhang C, Gu Q, Li L. (2007) Differential regulation of interleukin-1 receptor associated kinase 1 (IRAK1) splice variants.Mol Immunol.2007 Feb;44(5):900-5.
	Gan L, Li L. (2006) Regulations and Roles of the Interleukin-1 Receptor Associated Kinases   (IRAKs) In Innate and Adaptive Immunity. Immunologic Research. 2006;35(3):295-302.
	Li T, Hu J, Thomas J, and Li L. (2005) Differential regulation of apoptosis by LPS and taxol in THP-1 cells. Molecular Immunology. 42: 1049-1055.
	Su n J, Zheng S, Chang B, Li L, Li G, Liu W, Turner AR, Meyers DA, Isaacs EB, Xu J, Gr�nberg H. (2005) Sequence variants in Toll-like receptor gene cluster (TLR6-TLR1-TLR10) are associated with prostate cancer risk. Journal of the National Cancer Institute. 97: 525-532.
	Chan C, Li L, McCall CE, Yoza B. (2005) Endotoxin Tolerance Disrupts Chromatin Remodeling and NF-B Transactivation at the IL-1 Promoter. Journal of Immunology . 175: 461-468.
	Huang YS, Li T, Sane D, Li L. (2004) IRAK1 serves a novel regulator essential for IL-10 gene expression. J Biol Chem . 279:51697-51703.
	Li T, Hu J, and Li L*. (2004) Regulation of Tollip by lipopolysaccharide in THP-1 cells. Molecular Immunology. 41 (1):85-92.
	Li L* . (2004) Regulation of innate immunity signaling and its connection with human diseases. Current Drug targets-Inflammation & Allergy. 3: 81-86 .
	Jacinto R, Hu J, Hartung T, McCall CE, Li L*. (2002) LPS and LTA-induced tolerance and cross-tolerance: Distinct alterations in IRAK. Journal of Immunology. 168: 6136-6141.
	Moors M, Li L, Mizel S. (2001) Bacterial FliC protein activates macrophages via TLR-IRAK mediated pathway. Infection and Immunity. 69, 4424-4429.
	Learn C, Boger S, Li L*, McCall CE. (2001) Phosphortidyl-inositol-3-phosphate kinase selectively controls IL-1 RA protein production in tolerant cells. J Biol Chem. 276, 20234-9.
	Liwu Li , Jack Dixon. (2000) Form, function, and regulation of protein tyrosine phosphatases and their involvement in human diseases. Seminars in Immunology. 12 (1). 75-84.
	Liwu Li , Sue Coursat, Jean Hu, Charles McCall. (2000) Characterization of Interleukin-1 receptor associated kinase in normal and tolerant cells. Journal of Biological Chemistry.275, 23340-45.