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Liwu Li, Ph.D.
Associate Professor
Department of Biology
Program in Inflamation
206 Fralin Biotechnology Center
Blacksburg, VA 24061
540-231-1433
540-231-2317 (fax)
lwli@vt.edu
EDUCATION:
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Ph.D, Cell & Mol Biol., University of Michigan, 1996
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Post-doc, Biochemistry, University of Michigan, 1999
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RESEARCH INTERESTS:
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Cellular and molecular signaling events controlling innate immunity
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Innate immunity and the pathogenesis of atherosclerosis
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Innate immunity and cancer
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Innate immunity and host defense against infection
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Chemical and Biochemical intervention of innate immunity signaling
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RECENT PUBLICATIONS:
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Xie Q, Gan L, Wang J, Wilson I, Li L. (2007) Loss of the innate immunity negative regulator IRAK-M leads to enhanced host immune defense against tumor growth. Mol Immunol. 44:3453-3461.
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Su J, Richter K, Zhang C, Gu Q, Li L. (2007) Differential regulation of interleukin-1 receptor associated kinase 1 (IRAK1) splice variants.Mol Immunol.2007 Feb;44(5):900-5.
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Gan L, Li L. (2006) Regulations and Roles of the Interleukin-1 Receptor Associated Kinases (IRAKs) In Innate and Adaptive Immunity. Immunologic Research. 2006;35(3):295-302.
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Li T, Hu J, Thomas J, and Li L. (2005) Differential regulation of apoptosis by LPS and taxol in THP-1 cells. Molecular Immunology. 42: 1049-1055.
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Su n J, Zheng S, Chang B, Li L, Li G, Liu W, Turner AR, Meyers DA, Isaacs EB, Xu J, Gr�nberg H. (2005) Sequence variants in Toll-like receptor gene cluster (TLR6-TLR1-TLR10) are associated with prostate cancer risk. Journal of the National Cancer Institute. 97: 525-532.
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Chan C, Li L, McCall CE, Yoza B. (2005) Endotoxin Tolerance Disrupts Chromatin Remodeling and NF- B Transactivation at the IL-1 Promoter. Journal of Immunology . 175: 461-468.
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Huang YS, Li T, Sane D, Li L. (2004) IRAK1 serves a novel regulator essential for IL-10 gene expression. J Biol Chem . 279:51697-51703.
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Li T, Hu J, and Li L*. (2004) Regulation of Tollip by lipopolysaccharide in THP-1 cells. Molecular Immunology. 41 (1):85-92.
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Li L* . (2004) Regulation of innate immunity signaling and its connection with human diseases. Current Drug targets-Inflammation & Allergy. 3: 81-86 .
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Jacinto R, Hu J, Hartung T, McCall CE, Li L*. (2002) LPS and LTA-induced tolerance and cross-tolerance: Distinct alterations in IRAK. Journal of Immunology. 168: 6136-6141.
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Moors M, Li L, Mizel S. (2001) Bacterial FliC protein activates macrophages via TLR-IRAK mediated pathway. Infection and Immunity. 69, 4424-4429.
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Learn C, Boger S, Li L*, McCall CE. (2001) Phosphortidyl-inositol-3-phosphate kinase selectively controls IL-1 RA protein production in tolerant cells. J Biol Chem. 276, 20234-9.
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Liwu Li , Jack Dixon. (2000) Form, function, and regulation of protein tyrosine phosphatases and their involvement in human diseases. Seminars in Immunology. 12 (1). 75-84.
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Liwu Li , Sue Coursat, Jean Hu, Charles McCall. (2000) Characterization of Interleukin-1 receptor associated kinase in normal and tolerant cells. Journal of Biological Chemistry.275, 23340-45.
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