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Robert Grange, Ph.D.
 Associate Professor
Human Nutrition, Foods and Exercise
Virginia Tech
321 Wallace Hall
Blacksburg, VA 24061
540-231-2725
540-231-3916 (fax)
rgrange@vt.edu
EDUCATION:
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Ph.D., Kinesiology - University of Waterloo, Waterloo, Ontario, Canada. 1993.
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M.S., Kinesiology - University of Washington, Seattle, WA., U.S.A. 1984.
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B.S., Physical Education - University of British Columbia, Vancouver, British Columbia, Canada. 1979.
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RESEARCH INTERESTS:
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Pathogenic Mechanisms in Duchenne Muscular Dystrophy
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Muscle aging / fatigue / injury / repair; muscle mechanics/ contractile properties in vitro; validation of muscle properties in vivo using in vitro methods.
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RECENT PUBLICATIONS:
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Gainer, TG, Wang W, Ward CW and Grange RW. 2007. “Duchenne Muscular Dystrophy”. Chapter in,
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Skeletal Muscle Damage and Repair: Mechanisms and Interventions. Ed. By Peter M. Tiidus. Human Kinetics, Inc. Accepted
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Lund, TC, Grange RW and DA Lowe. 2007. Telomere shortening in diaphragm and tibialis anterior muscles of aged mdx mice. Muscle and Nerve, Accepted
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Grange, RW and JA Call. 2007. Recommendations to define exercise prescription for Duchenne muscular dystrophy. Ex, and Sports Sci, Rev. 35(1):12-17.
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Liu M, Yue Y, Harper SQ, Grange RW, Chamberlain JS, and Duan D. 2004. Adeno-associated Virus-mediated Micro-dystrophin Expression Protects Young Mdx Muscle. Mol. Ther. In Press.
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Draper KE, Wang Q, Williams BO, and Grange RW. 2004. "Duchenne Muscular Dystrophy", in Encyclopedia of Neuroscience. Springer. In Press.
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Chin ER, Grange RW, Viau F, Humphries C, Shelton J, Bassel-Duby R, Michel RN, and Sanders Williams R. 2003. Phenotypic alterations in slow-twitch muscle from transgenic mice overexpressing the Ca2+ buffering protein parvalbumin. J. of Physiology (London), 547:649-663.
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Grange RW, Gainer T, Marschner KM, Talmadge RJ and Stull JT. 2002. Fast-twitch skeletal muscles of dystrophic mouse pups are resistant to injury from acute mechanical stress. Am. J. Physiol. (Cell 283): 1090-1101.
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Grange RW, Meeson A, Chin ER, Lau KS, Stull JT, Shelton JM, Sanders Williams R, and Garry DJ. 2001. Functional and molecular adaptations in skeletal muscle of myoglobin mutant mice. Am.J. Physiol. (Cell 281): C1487-C1494.
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Grange RW, Isotani E, Lau KS, Kamm KE, and Huang PL, and Stull JT. 2001. Nitric oxide contributes to vascular smooth muscle relaxation in contracting fast-twitch skeletal muscles. Physiol. Genomics. 5: 35-44, 2001.
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Lau KS, Grange RW, Isotani E, Sarelius IH, Kamm KE, Huang PL and Stull JT. 2000. nNOS and eNOS modulate cGMP formation and vascular responsiveness in contracting fast-twitch skeletal muscle. Physiol. Genomics. 2(1): 21-27.
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Sanchez JA, Ho CS, Vaughan DM, Garcia MC, Grange RW, Joho RH. 2000. Muscle and motor-skill dysfunction in a K+ channel -deficient mouse are not due to altered muscle excitability or fiber type but depend on the genetic background. Pflueger's Archives (Eur. J. of Physiol.). 440(1): 34-41.
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Grady RM, Grange RW, Lau KS, Maimone MM, Nichol MC, Stull JT, and Sanes JR. 1999. Role for ?-dystrobrevin in the pathogenesis of dystrophin-dependent muscular dystrophies. Nature (Cell Biology). 1(4): 215-220.
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Garry DJ, Ordway GA, Lorenz JN, Radford NB, Chin ER, Grange RW, Bassel-Duby R, and Sanders-Williams R. 1998. Mice without myoglobin. Nature 395:905-908.
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Lau KS, Grange RW, Chang W-J, Kamm KE, Sarelius I, and Stull JT. 1998. Skeletal muscle contractions stimulate cGMP formation and attenuate vascular smooth muscle myosin phosphorylation via nitric oxide. FEBS Lett. 431:71-74.
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Grange RW, Vandenboom R, Xeni J, and Houston ME. 1998. Potentiation of in vitro concentric work in mouse fast muscle. J. Appl. Physiol. 84(1): 236-243.
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Ziang Z., Grange RW, Walsh MP and Kamm KE. 1997. Adenovirus-mediated transfer of the smooth muscle cell calponin gene inhibits proliferation of smooth muscle cells and fibroblasts. FEBS Lett. 413:441-445.
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Ho CS, Grange RW, and Joho RH. 1997. Pleiotropic effects of a disrupted K+ channel gene: reduced body weight, impaired motor skill and muscle contraction, but no seizures. Proc. Natl. Acad. Sci. 94:1533-1538.
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Stidham DB, Stager DR, Kamm KE and Grange RW. 1997. Stiffness of the inferior oblique neurofibrovascular bundle. Inv. Ophtham. Vis. Sci. 38(7):1314-1320.
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Kamm KE and Grange RW. 1996. "Calcium sensitization of contraction", Chapter 27 in, Biochemistry of Smooth Muscle Contraction. Michael Barany, Ed. Academic Press.
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Houston ME and Grange RW. 1991. Torque potentiation and myosin light chain phosphorylation in human muscle following a fatiguing contraction. Can. J. Physiol. Pharmacol. 69:269-273.
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Grange RW and Houston ME. 1991. Simultaneous potentiation and fatigue in quadriceps after a 60-second maximal voluntary contraction. J. Appl. Physiol. 70(2):726-731.
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Houston ME and Grange RW. 1990. Myosin phosphorylation, twitch potentiation, and fatigue in human skeletal muscle. Can. J. Physiol. Pharmacol. 68:908-913.
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Moore RL, Palmer BM, Williams SL, Tanabe H, Grange RW, and Houston ME. 1990. Effect of temperature on myosin phosphorylation in mouse skeletal muscle. Am. J. Physiol. 259(Cell Physiol. 28): C432-C438.
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Stuart DS, Lingley MD, Grange RW, and Houston ME. 1988. Myosin light chain phosphorylation and contractile performance of human skeletal muscle. Can. J. Physio Pharmacol. 66:49-54.
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Houston ME, Lingley MD, Stuart DS, and Grange RW. 1987. Myosin light chain phosphorylation in intact muscle. FEBS Lett. 469-471.
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Anderson B. , S. Christiansen, S. Grandt, R. Grange and L. McLoon. 2006. Increased Extraocular Muscle Strength with Direct Injection of Insulin-like Growth Factor I. Inv Ophthal & Vis Sci. In press.
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Pline K., M. Madigan, M. Nussbaum and R. Grange. 2005. Lumbar extensor fatigue and Circumferential Ankle Pressure Impair Ankle Joint Motion Sense. Neurosci. Lett. 390(1):9-14
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Liu D., H. Jiang and R. Grange. 2005. Genistein activates the cAMP signaling pathway in vascular endothelial cells and protects endothelial barrier function. Endocrin. 146: 1312-1320.
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Book chapter: Gainer, TG, W. Wang and Grange RW. 2007. Duchenne Muscular Dystrophy. Chapter in, Skeletal Muscle Damage and Repair: Mechanisms and Interventions. Ed. By Peter M. Tiidus. Human Kinetics, Inc. Accepted.
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