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J. Jeffrey Carr, M.D., M.S.
 Vice-Chair Clinical Research
Professor of Radiologic Sciences
Professor of Public Health Sciences
Wake Forest University Health Sciences
Image Lab
2000 West First Street, Suit 618
Winston-Salem, NC 27104
EDUCATION:
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B.A., Vanderbilt University, Nashville, TN
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M.D., Vanderbilt University School of Medicine, Nashville, TN
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M.S., Clinical Epidemiology, Wake Forest University
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RESEARCH INTERESTS:
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Improving our understanding of the development and promotion of atherosclerosis from subclinical to clinical disease by applying imaging technologies to population-based epidemiological and genetic studies in humans and animals.
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RECENT PUBLICATIONS:
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Hiatt MD, Carr JJ, Manning RL. The length of time necessary to break even after converting to a digital mammographic system. J Telemed Telecare: 6(4):222-4; 9910-4.1-9910-4.3; 2000.
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Carr JJ, Burke GL. Subclinical cardiovascular disease and atherosclerosis are not inevitable consequences of aging. J Am Geriatr Soc: 48(3):342-343; Mar 2000.
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Carr JJ, Crouse JR III, Goff DC Jr, D’Agostino RB Jr, Peterson NP, Burke GL. Evaluation of subsecond gated helical CT for quantification of coronary artery calcium and comparison with electron beam CT. Am J Roentgenol: 174(4):915-921; Apr 2000.
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Carr JJ. Coronary Calcium: The case for helical computed tomography. J Thoracic Imaging: 16(1):16-24; Jan 2001.
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Carr JJ, Hemler PF, Halford PW, Freimanis RI, Choplin RH, Chen MY. Stereotactic localization of breast lesions; how it works and methods to improve accuracy. Radiographics:21(2):463-473; Mar-Apr 2001.
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Wagenknecht LE, Bowden DW, Carr JJ, Langefeld CD, Freedman BI, Rich SS. Familial aggregation of coronary artery calcium in families with Type 2 diabetes. Diabetes: 50(4):861-866; Apr 2001.
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Carr JJ, Danitschek JA, Goff DC, Crouse JR III, D’Agostino R, Chen MYM, Burke GL. Coronary artery calcium quantification with retrospectively gated helical CT: Protocols and Techniques. Intern J Cardiovasc Imaging: 17(3):213-220; Jun 2001.
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Longstreth WT, Dulberg C, Manolio T, Lewis M, Beauchamp N, O’Leary D, Carr JJ, Furberg CD. Incidence, manifestations, and predictors of brain infarcts defined by serial cranial magnetic resonance imaging in the elderly. The Cardiovascular Health Study. Stroke: 33(10):2376-2382; 2002.
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Bild DE, Bluemke DA, Burke GL, Detrano R, Roux AVD, Folsom AR, Greenland P, Jacobs DR Jr, Kronmal R, Liu K, Nelson JC, O’Leary D, Saad MF, Shea S, Szklo M, Tracy R. Multi-ethnic study of atherosclerosis: objectives and design. Am J Epidemiol: 156 (9):871-881; 2002.
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Lange LA, Bowden DW, Langefeld CD, Wagenknecht LE, Carr JJ, Rich SS, Riley WA, Freedman BI. Heritability of carotid artery intima-medial thickness in Type 2 diabetes. Stroke: 33(7):1876-1881; Jul 2002.
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Zhao L, Freimanis R, Bergman S, Shen P, Perrier ND, Lesko N, Pulaski T, Pulaski S, Carr JJ, Levine EA. Biopsy needle technique and the accuracy of diagnosis of atypical ductal hyperplasia for mammographic abnormalities. Am Surg: 69(9):757-762; Sept 2003.
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Lenchik L, Register TC, Hsu FC, Lohman K, Nicklas BJ, Freedman BI, Langefeld CD, Carr JJ, Bowden DW. Adiponectin as a novel determinant of bone mineral density and visceral fat. Bone: 33(4):646-651; Oct 2003.
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Longstreth WT Jr, Katz R, Olson J, Bernick C, Carr JJ, Malinow MR, Hess DL, Cushman M, Schwartz SM. Plasma total homocysteine levels and cranial magnetic resonance imaging findings in elderly persons: The Cardiovascular Health Study. Arch of Neurol: 61(1):67-72; Jan 2004.
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Lenchik L, Shi R, Register TC, Beck SR, Langefeld CD, Carr JJ. Measurement of trabecular bone mineral density in the thoracic spine using cardiac gated quantitative computed tomography. J Comput Assist Tomogr: 28(1):134-9; Jan-Feb 2004.
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Freedman BI, Hsu FC, Langefeld CD, Bowden DW, Moossavi S, Dryman BN, Carr JJ. Renal artery calcified plaque associations with subclinical renal and cardiovascular disease. Kidney Int.: 65(6):2262-67; Jun 2004.
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Wagenknecht LE, Langefeld CD, Carr JJ, Riley W, Freedman BI, Moossavi S, Bowden DW. Race-specific relationships between coronary and carotid artery calcification and carotid intimal medial thickness. Stroke. 2004 May;35(5):e97-9. Epub 2004 Apr 8.
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Lenchik L, Hsu FC, Register TC, Lohman KK, Freedman BI, Langefeld CD, Bowden DW, Carr JJ. Heritability of spinal trabecular volumetric bone mineral density Measured by QCT in the Diabetes Heart Study. Calcif Tissue Int: 75(4):305-312; Oct 2004; Epub Jul 30, 2004.
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Register TC, Burdon KP, Lenchik L, Bowden DW, Hawkins GA, Nicklas BJ, Lohman K, Hsu FC, Langfeld CD, Carr JJ. Variability of serum soluble intercellular adhesion molecule-1 measurements Attributable to a common polymorphism. Clin Chem.: 50(11):2185-7; Nov 2004.
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Folsom AR, Evans GW, Carr JJ, Stillman AE; Atherosclerosis Risk in Communities Study Investigators. Association of traditional and non-traditional cardiovascular risk factors with coronary artery calcification. Angiology: 55(6):613-623; Nov-Dec 2004.
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Carr JJ, Nelson JC, Wong ND, McNitt-Gray M, Arad Y, Jacobs DR Jr, Sidney S, Bild DE, Williams OD, Detrano RC. Calcified Coronary Artery Plaque Measurement with Cardiac CT in Population Based Studies: The Standardized Protocol of the Multi-Ethnic Study of Atherosclerosis (MESA) and Coronary Artery Risk Development in Young Adults (CARDIA). Radiology: 234(1):35-43; Jan 2005.
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Wheeler GL, Shi R, Beck SR, Langefeld CD, Lenchik L, Freedman BI, Rich SS, Bowden DW, Chen MY, Wagenknecht L, Carr JJ. Pericardial and Visceral Adipose Tissues Measured Volumetrically with Computer Tomography are Highly Associated in Type 2 Diabetic Families: Results of a Preliminary Study. Investigative Radiology: 40(2):97-101; Feb 2005.
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Taylor BC, Schreiner PJ, Doherty TM, Fornage M, Carr JJ, Sidney S. Matrix Gla Protein and Osteopontin Genetic Associations with Coronary Artery Calcification and Bone Density: The CARDIA Study. Hum Genet: 116(6); 525-528; May 2005; Epub Mar 3, 2005.
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Nelson JC, Kronmal RA, Carr JJ, McNitt-Gray MF, Wong ND, Loria CM, Goldin JG, Williams OD, Detrano R. Measuring coronary calcium on CT images adjusted for attenuation differences. Radiology: 235(2):403-14; May 2005.
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Ellison RC, Zhang Y, Wagenknecht LE, Eckfeldt JH, Hopkins PN, Pankow JS, Djousse L, Carr JJ. Relation of the Metabolic Syndrome to Calcified Atherosclerotic Plaque in the Coronary Arteries and Aorta. Am J Cardiol: 95(10):1180-6; May 15, 2005.
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Djousse L, Arnett DK, Carr JJ, Eckfeldt JH, Hopkins P, Province MA, Ellison RC; Investigators of the NBLBI FHS. Dietary Linolenic acid is inversely associated with calcified atherosclerotic plaque in the coronary arteries: The NHLBI Family Heart Study. Circulation 2005 Jun 7; 111(22):2921-6. Epub 2005 May 31.
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Freedman BI, Langefeld CD, Lohman KK, Bowden DW, Carr JJ, Rich SS, Wagenknecht LE. Relationship between Albuminuria and Cardiovascular Disease in Type 2 Diabetes. J Am Soc Nephrol: 16(7):2156-61; Jul 2005. Epub May 4, 2005.
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Burdon KP, Langefeld CD, Beck SR, Wagenknecht LE, Carr JJ, Freedman BI, Herrington D, Bowden DW. Association of genes of lipid metabolism with measure of subclinical cardiovascular disease in the Diabetes Heart Study. J Med Genet: 2005 Sep; 42(9): p 720-4.
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Bowden DW, Lange LA, Langefeld CD, Brosnihan KB, Freedman BI, Carr JJ, Wagenknecht LE, Herrington DM. The relationship between C-reactive protein and subclinical cardiovascular disease in the Diabetes Heart Study (DHS). Am Heart J. 2005 Nov; 150(5):1032-1038.
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Pletcher MJ, Kiefe CI, Sidney S, Carr JJ, Lewis CE, Huley SB. Cocaine and coronary calcification in young adults: the Coronary Artery Risk Development in Young Adults (CARDIA) Study. Am Heart J: 2005 Nov; 150(5):921-6.
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Freedman BI, Hsu FC, Landefeld CD, Rich SS, Herrington DM, Carr JJ, Xu j, Bowden DW, Wagenknecht LE. The Impact of Ethnicity and Gender on Subclinical Cardiovascular Disease: The Diabetes Heat Study. Diabetologia 2005 Dec;: 48(12):25111-8. Epub 2005 Nov 1.
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Budoff M, Takasu J, Katz R, Mao S, Shavelle DM, O’Brien KD, Blumenthal RS, Carr JJ, Kronmal RA. Reproducibility of CT measurements of aortic valve calcification, mitral annulus calcification, and aortic wall calcification in the Multi-Ethnic Study of Atherosclerosis. Acad Radiol 2006 Feb; 13(2):166-172.
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Edvardsen T, Detrano R, Rosen BD, Carr JJ, Liu K, Lai S, Shea S, Pan L, Bluemke DA, Lima JA. Coronary artery atherosclerosis is related to reduce regional left ventricular function in individuals without history of clinical cardiovascular disease: the Multiethnic Study of Atherosclerosis. Arterioscler Thromb Vasc Biol. 2006 Jan;26(1):206-11. (Epub 2005 Nov 3.)
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Hozawa A, Houston T, Steffes MW, Widome R, Williams OD, Iribarren C, Pletcher MJ, Daviglus ML, Carr JJ, Jacobs DR. The association of cigarette smoking with self-reported disease before middle age: the coronary Artery Risk Development in Young Adults (CARDIA) Study. Prev Med 2006 Mar; 42(3): 193-9. (Epub 2006 Feb 15.)
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Register TC, Lenchik L, Hsu FC, Lohman KK, Freedman BI, Bowden DW, Carr JJ. Type 2 diabetes is not independently associated with spinal trabecular volumetric bone mineral density measured by QCT in the Diabetes Heart Study. Bone. 2006 May 9. (Epub ahead of print.)
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Hopkins PN, Ellison RC, Province MA, Pankow JS, Carr JJ, Arnett DK, Lewis CE, Heiss G, Hunt SC. Association of Calcified Coronary Artery Plaque with Clinical Coronary Heart Disease in the National Heart, Lung and Blood Institute’s Family Heart Study. Am J Cardiol 2006 Jun 1; 97(11):1564-9. (Epub 2006 Apr 17.)
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Bowden DW, Rudock M, Ziegler J, Lehtinen AB, Xu Jianzhao, Wagenknecht LE, Herrington D, Rich SS, Freedman BI, Carr JJ, Langefeld CD. Linkage Mapping of Combined Type 2 Diabetes, Metabolic Syndrome, and Measure of Cardiovascular Disease in a Genome Scan of the Diabetes Heart Study. Diabetes. 2006 Jul; 55(7): 1985-94.
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Bowden DW, Lohman K, Hsu F-C, Langefeld CD, Carr JJ, Lenchik L, Wagenknecht LE, Freedman BI, Herrington DM. Hormone Replacement Therapy is Associated with Increased C-reactive Protein in Women with Type 2 Diabetes in the Diabetes Heart Study. Diabet. Med. 2006 Jul: 23, 763-767.
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Ellison RC, Zhang Y, Hopkins PN, Knox S, Djoussé L, Carr JJ. Is alcohol consumption associated with calcified atherosclerotic plaque in the coronary arteries and aorta? Am Heart J 2006 July; 152(1): 177-82.
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Bowden DW, Lohman K, Hsu FC, Langefeld CD, Carr JJ, Lenchik L, Wagenknecht LE, Freedman BI, Herrington DM. Hormone replacement therapy is associated with increased C-reactive protein in women with Type 2 diabetes in the Diabetes Heart Study. Diabet Med. 2006 Jul;23(7):763-7. PMID: 16842481 [PubMed - in process]
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North KE, Carr JJ, Borecki I, Kraja A, Province M, Pankow J, Wilk J, Heiss G. QTL Specific Genotype by smoking interaction and burden of coronary atherosclerosis: The NHLBI Family Heart Study. Atherosclerosis Sep 9, 2006 [Epub ahead of print].
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Budoff MJ, Achenbach S, Blumenthal RS, Carr JJ, Goldin JG, Greenland P, Guerci AD, Lima JA, Rader DJ, Rubin GD, Shaw IJ, Wiegers, SF. Assessment of Coronary Artery Disease by Cardiac Computed Tomography, A Scientific Statement from the American Heart Association Committee on Cardiovascular Imaging and Intervention, Council on Cardiovascular Radiology and Intervention, and Committee on Cardiac Imaging, Council on Clinical Cardiology. Circulation. Oct 2, 2006 [Epub ahead of print].
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Fukuta H, Ohte N, Brucks S, Carr JJ, Little WC. Contribution of right-sided heart enlargement to cardiomegaly on chest roentgenogram in diastolic and systolic heart failure. Am J Cardiol. 2007 Jan 1; 99(1):62-7. Epub 2006 Nov 3. PMID: 17196464 [PubMed - in process].
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Terry J, Carr JJ, Kouba E, Davis D, Menon L, Bender K, Chandler T, Morgan T, Crouse J. Effect of Simvastatin (80mg) on Coronary and Abdominal Aortic Areterial Calcium (From the Coronary Artery Calcification Treatment with Zocor [CATZ] Study). Am J Cardiol. [In Press June 2007].
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